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• CEA-Scan® (arcitumomab)
is a murine monoclonal IgG antibody Fab’ fragment
that targets tumors that have carcinoembryonic antigen
(CEA) on their cell membrane. The fragment is labeled
with the isotope technetium-99m and images are produced
using a gamma camera. CEA-Scan can detect the presence,
location and extent of metastasis or recurrence of
colorectal cancer. This product is approved in Australia,
Canada, Europe and the US.
• LeukoScan® (sulesomab) is a murine monoclonal
IgG antibody Fab’ fragment labeled with the
isotope technetium-99m. The fragment targets NCA-90,
found on the cell membrane of graunlocytes (a type
of white blood cell). Using a gamma camera, LeukoScan
can be used to detect osteomyelitis (a bone infection).
LeukoScan is not available in North America, but it
has European-wide registration and it is also approved
in Australia.
• ImmuSTRIP is an ELISA method immunoassay
laboratory test kit used to detect Human Anti-Murine
Antibodies (HAMA). Using this kit, clinicians can
determine if their patients have preexisting HAMA
or have developed HAMA due to recent treatments with
murine monoclonal antibodies. ImmuSTRIP is a simple
to use test kit that provides results in as little
as one hour and is available for use by reference
laboratories.
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